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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Palmitoyl pentapeptide-4 ： ウィキペディア英語版 Palmitoyl pentapeptide-4 |Section2= }} Palmitoyl pentapeptide-4 (palmitoyl pentapeptide-3 before 2006) is a matrikine used in anti-wrinkle cosmetics. It was launched in 2000 as an active ingredient for the personal care industry under the trade name Matrixyl by the French cosmetic active ingredient manufacturer Sederma SAS. ==Chemistry== Palmitoyl pentapeptide-4 (Pal-Lys-Thr-Thr-Lys-Ser = Pal-KTTKS) contains 5 amino acids linked to a 16-carbon aliphatic chain for improving the penetration of the molecule through the lipid structures of the skin. It is a matrikine. Matrikines are messenger peptides capable of regulating cell activities by interacting with their specific receptors. They activate certain genes involved in the process of extracellular matrix renewal and cell proliferation.〔MAQUART FX. et al, 1999, Régulation de l’activité cellulaire par la matrice extracellulaire : le concept de Matrikines, Journal de la Société de Biologie, 193, (4), p 423.〕 By activating the neosynthesis of extracellular matrix macromolecules, palmitoyl pentapeptide-4 provides an anti-wrinkle effect. Studies (''in vitro'' and ''in vivo'') demonstrating the anti-wrinkle efficacy of this peptide have been conducted and published by Sederma and by independent organisations.〔Roanne R. Jones , Valeria Castelletto , Che J. Connon , and Ian W. Hamley, Mol. Pharmaceutics, 2013, 10 (3), pp 1063–1069)〕〔Peschard O. and Lintner K., Biologically active peptides : from a laboratory bench curiosity to a functional skin care product, International Journal of Cosmetic Science, 22, 207-218 (2000)〕〔Lintner K., Mondon P., Peschard O. and Mas-Chamberlin C., Cosmetic applications of a wound healing peptide, Journal of Cosmetic Science, 52 (1), 82-83 (2001)〕〔Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL, Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin, Int J Cosmet Sci. 2005 Jun;27(3):155-60〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Palmitoyl pentapeptide-4」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.